Olaparib and adavosertib work best when given sequentially for DNA-damage response mutations in advanced tumors

Patients with cancers that are driven by certain mutations occurring in response to DNA damage can be safely treated with two drugs, olaparib and adavosertib, if they are given in sequence rather than concurrently. Presenting results from the phase Ib STAR clinical trial to the 34th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in […]

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Wearable device study in 88,000 people shows the heart health benefits of more intense physical activity

Increasing physical activity of any intensity is beneficial for health, but new research published today in the European Heart Journal shows that there is a greater reduction in cardiovascular disease risk when more of that activity is of at least moderate intensity. The study, led by researchers at the National Institute for Health and Care […]

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Exercise testing detects silent cardiovascular dangers common in pediatric cancer survivors

Cardiopulmonary exercise testing (CPET) can detect underlying early signs of cardiovascular problems in asymptomatic pediatric cancer survivors that other types of monitoring cannot, according to a study led by Nemours Children’s Health, published in the journal Pediatric Cardiology. The findings are vital for hundreds of thousands of people in the U.S. who have survived childhood […]

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New study sheds light on basic biology of frontotemporal dementia

Dementia encompasses a range of neurodegenerative conditions that lead to memory loss and cognitive deficiencies and affect some 55 million people worldwide. Yet despite its prevalence, there are few effective treatments, in part because scientists still don’t understand how exactly dementia arises on a cellular and molecular level. Now, a team led by scientists at […]

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Battery-free, light-powered pacemaker may improve quality of life for heart disease patients

Atrial fibrillation—a form of irregular heartbeat, or arrhythmia—leads to more than 454,000 hospitalizations and nearly 160,000 deaths in the United States each year. Globally, it is estimated that approximately 60 million people are affected by the condition. Pacemakers are lifesaving devices that regulate the heartbeats of people with chronic heart diseases like atrial fibrillation and […]

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